Rb Polyclonal Antibody, 100ul[BT-AP07694] Electrophoresis & Labeling Two protein-coding transcripts and one

Two protein-coding transcripts and one non-protein coding transcript have been found for this gene

The encoded protein (EPS8 like 2)

All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins

Mutations in this gene are associated with Hermansky-Pudlak syndrome type 6

Rb Polyclonal Antibody, 100ul[BT-AP07694] Electrophoresis & Labeling Two protein-coding transcripts and oneThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.