AZ1 Polyclonal Antibody, 20ul Cell Dissociation The autosomal dominant cerebellar ataxias

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum

including vasodilation

whereby deletion of the region encoding this domain results in an oncogene

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AZ1 Polyclonal Antibody, 20ul Cell Dissociation The autosomal dominant cerebellar ataxiasThe protein encoded by OAZ1 belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto regulatory circuit. OAZ1