p53(Phospho Thr18) Polyclonal Antibody, 100ul Cell Function Analysis Most members of family 1

Most members of family 1 have two conserved glutamic acid residues| which are required for enzymatic activity

Mutations in this gene are associated with forebrain defects

RIN1 is localized primarily to the plasma membrane

This protein is widely expressed in various types of tissues with a high expression level in thyroid gland

p53(Phospho Thr18) Polyclonal Antibody, 100ul Cell Function Analysis Most members of family 1This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.