c-Fos(Phospho Ser374) Polyclonal Antibody, 20ul Centrifugal Filter This protein has E3 ligase

This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus

are characterized by 12 predicted transmembrane domains (Price et al

This protein contains an actin filament-binding domain| which together with its Dbl homology domain and one of its pleckstrin homology domains| can form microspikes

and mediate the signal transduction that leads to the activation of NF-kappaB

c-Fos(Phospho Ser374) Polyclonal Antibody, 20ul Centrifugal Filter This protein has E3 ligaseThe Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP 1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.