GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes Alternatively spliced transcript variants containing

Alternatively spliced transcript variants containing different 5' UTRs

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and mutations in this gene have been associated with different neuromuscular diseases

This gene encodes a member of the highly conserved cyclin C subfamily

GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes Alternatively spliced transcript variants containingThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.