YTHD2 Polyclonal Antibody, 50ul Subcellular Fractions EPCAM encodes a carcinoma-associated antigen

EPCAM encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins

Studies in mice show that this gene is expressed during embryonic development

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

The membrane-bound form promotes adhesion of those leukocytes to endothelial cells

YTHD2 Polyclonal Antibody, 50ul Subcellular Fractions EPCAM encodes a carcinoma-associated antigenThis gene encodes a member of the YTH (YT521 B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu rich domain has been identified in one of the