PKR(Phospho Thr258) Polyclonal Antibody, 100ul Contamination Detection & Removal cofactor:Binds 1 calcium ion per

cofactor:Binds 1 calcium ion per subunit

This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus

The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation| apoptosis| differentiation| the stress response| and regulation of immune genes

and MAPK kinase kinase (MAPKKK or MEKK)

PKR(Phospho Thr258) Polyclonal Antibody, 100ul Contamination Detection & Removal cofactor:Binds 1 calcium ion perThe protein encoded by this gene is a serine threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.