p53 Polyclonal Antibody, 100ul[BT-AP06814] Recombinant Protein Expression 2002 [PubMed 11836249])

2002 [PubMed 11836249])

The protein (minichromosome maintenance complex component 2) encoded by MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication

This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation

and may contribute to the antiviral activity of CD8(+) T-cells

p53 Polyclonal Antibody, 100ul[BT-AP06814] Recombinant Protein Expression 2002 [PubMed 11836249])TP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni