ERK 8(Phospho Thr175/Y177) Polyclonal Antibody, 50ul Bio-Reaction Tube Increases p53/TP53-dependent transcription and apoptosis

Increases p53/TP53-dependent transcription and apoptosis

There are at least two protein isoforms of the Double C2 protein| namely alpha (DOC2A) and beta (DOC2B)| which contain two C2-like domains

two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase

Similar to STAM| this protein acts downstream of JAK kinases| and is phosphorylated in response to cytokine stimulation

ERK 8(Phospho Thr175/Y177) Polyclonal Antibody, 50ul Bio-Reaction Tube Increases p53/TP53-dependent transcription and apoptosisCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,The N terminal region (1 20) is the minimal region necessary for ubiquitination and further proteosomal degradation.,The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1.,In vitro, phosphorylates MBP.,PTM: