CCBE1 Polyclonal Antibody, 20ul DNA Fragments tissue specificity:Not expressed in normal

tissue specificity:Not expressed in normal tissues except in testis

Also interacts with MAP3K8

However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase

It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules

CCBE1 Polyclonal Antibody, 20ul DNA Fragments tissue specificity:Not expressed in normalThis gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia lymphedema syndrome, a generalized lymphatic dysplasia in humans.