DEN1B Rabbit Polyclonal Antibody, 50ul Proteases It has been identified that

It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD)

Proteins expressed using the baculovirus-insect expression system retain full biological functionality and can accommodate larger exogenous fragments

The protein encoded by this gene is a component of an evolutionarily conserved

This gene encodes a member of the membrane-spanning 4A gene family| members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues

DEN1B Rabbit Polyclonal Antibody, 50ul Proteases It has been identified thatClathrin (see MIM 118955) mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family such as DENND1B function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein 2 (AP2; see MIM 601024). Thus connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson 2010