Topo II Alpha Polyclonal Antibody, 50ul[BT-AP09133] Immunology Defects in SERPINE1 are the

Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency)

in isoprenoid and sterol synthesis

The encoded protein is localized to the cytosol and mitochondria| and associates with membranes through an isoprenyl modification near the C-terminus

and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55

Topo II Alpha Polyclonal Antibody, 50ul[BT-AP09133] Immunology Defects in SERPINE1 are theTOP2A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering