MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody, 20ul Dialysis Mutations in this gene have

Mutations in this gene have been associated with obesity and mood disorders

The encoded protein functions as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases

An important paralog of this gene isHNRNPCL3

MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody, 20ul Dialysis Mutations in this gene havealternative products: Additional isoforms seem to exist Catalytic activity: Cleaves aggrecan at the 360 Ser Phe 361 site. cofactor: Binds 1 zinc ion per subunit. cofactor: Calcium. disease: May play a role in pathological processes participating in rheumatoid arthritis (RA) associated joint tissue destruction. Autoantigen anti MMP19 are frequent in RA patients. The conserved cysteine present in the cysteine switch motif binds the catalytic zinc ion