Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 20ul Deep Well Plates Overexpression of the TCL1 gene

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors

One of two major clathrin-associated adaptor complexes

Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres

Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 20ul Deep Well Plates Overexpression of the TCL1 geneAlpha chains of type IV collagen have a non collagenous domain (NC1) at their C terminus frequent interruptions of the G X Y repeats in the long central triple helical domain (which may cause flexibility in the triple helix) and a short N terminal triple helical 7S domain. Type IV collagen is the major structural component of glomerular basement membranes (GBM) forming a 'chicken wire' meshwork together with laminins proteoglycans and entactin