HERC3 Rabbit Polyclonal Antibody, 20ul Drug Development and Evaluation The composition of the APC

The composition of the APC is highly conserved in organisms from yeast to humans

Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8

RAD52 homolog

This enzyme is highly expressed in pregnant uterus

HERC3 Rabbit Polyclonal Antibody, 20ul Drug Development and Evaluation The composition of the APCThis gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.