Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Constitutive activation of this gene

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

The transforming protein that results is implicated in various malignancies

the level of this protein in plasma increases greatly during acute phase response to tissue injury

Chromobox protein homolog 5 is enriched in the heterochromatin and associated with centromeres

Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Constitutive activation of this geneThis gene encodes a GTPase activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on