MIB2 Polyclonal Antibody, 50ul Yeast Expression The TRIM motif includes three

The TRIM motif includes three zinc-binding domains| namely a RING| a B-box type 1 and a B-box type 2| and a coiled-coil region

POLD3 encodes the 66-kDa subunit of DNA polymerase delta

The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle

Transcript variants encoding different isoforms have been identified for this gene

MIB2 Polyclonal Antibody, 50ul Yeast Expression The TRIM motif includes threeE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result