p53(Phospho-Ser366) Polyclonal Antibody, 50ul Custom RNA Oligos The encoded enzyme is a

The encoded enzyme is a membrane-bound zinc-dependent metalloprotease

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer

Shows a preference for cleavage after small polar residues and before basic residues

Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN)

p53(Phospho-Ser366) Polyclonal Antibody, 50ul Custom RNA Oligos The encoded enzyme is aThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.