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SB-705498 - CAS# 501951-42-4 Catalog No.:M10538-2 Ezogabine works primarily as a

SB-705498 - CAS# 501951-42-4 Catalog No.:M10538-2 Ezogabine works primarily as a

Name: SB-705498 - CAS# 501951-42-4 Catalog No.:M10538-2 Ezogabine works primarily as a
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SB-705498 - CAS# 501951-42-4 Catalog No.:M10538-2 Ezogabine works primarily as aSB 705498 is an orally bioavailable, competitive antagonist of the capsaicin mediated activation of TRPV1 receptors (pKis = 7. 6, 7. 5, and 7. 3 for human, rat, and guinea pig, respectively). SB 705498 inhibits the capsaicin , acid , and heat mediated activation of the receptor. SB 705498 was shown to be a potent competitive antagonist of the capsaicin mediated activation of the human TRPV1 receptor (pK(i) = 7. 6) with activity at rat (pK(i) = 7. 5)

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Description

Ezogabine works primarily as a potassium channel opener—that is

9'-xanthene]-6-carboxylic acid

21)22)8(18)3-24-10/h2-6H

CAS Number: 63590-64-7

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