LY2603618 alog-1 Chanan-Khan A

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LY2603618 alog-1 Chanan-Khan ARabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP dependent serine threonine kinase, is a key component in the DNA replication monitoring checkpoint

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